Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs. Academic Article uri icon

Overview

abstract

  • Semi-synthetic water-soluble analogs were synthesized from nocathiacin I through the formation of a versatile intermediate nocathiacin amine 5, and subsequent transformation via reductive amination, acylation or urea formation. Several of the novel analogs displayed much improved aqueous solubility over 1, while retained antibacterial activity. Compound 15 and 16 from the amide series, demonstrated excellent in vitro and in vivo antibacterial activity.

publication date

  • October 23, 2012

Research

keywords

  • Anti-Bacterial Agents
  • Peptides
  • Peptides, Cyclic
  • Thiazoles

Identity

Scopus Document Identifier

  • 84870977221

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2012.10.065

PubMed ID

  • 23164707

Additional Document Info

volume

  • 23

issue

  • 1