The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir. Review uri icon

Overview

abstract

  • Boceprevir and telaprevir are peptidomimetic serine protease inhibitors that have been recently approved for the treatment of HCV chronic infection. The addition of these drugs to the prior standard of care, pegylated interferon and ribavirin, improves sustained virological response rates for treatment-naive and treatment-experienced patients and shortens the duration of treatment for over half of treatment-naive patients. This review describes the clinical data supporting the approval and use of telaprevir and boceprevir, the algorithm for the use of these drugs, their adverse effects, as well as their important drug-drug interactions.

publication date

  • October 5, 2012

Research

keywords

  • Antiviral Agents
  • Hepacivirus
  • Hepatitis C, Chronic
  • Oligopeptides
  • Proline
  • Serine Proteinase Inhibitors

Identity

Scopus Document Identifier

  • 84867272904

Digital Object Identifier (DOI)

  • 10.3851/IMP2424

PubMed ID

  • 23188750

Additional Document Info

volume

  • 17

issue

  • 6 Pt B