Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. uri icon

Overview

abstract

  • Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

publication date

  • January 6, 2013

Research

keywords

  • Antineoplastic Agents
  • Desmoplastic Small Round Cell Tumor
  • Indoles
  • Pyrroles

Identity

Scopus Document Identifier

  • 84884285656

Digital Object Identifier (DOI)

  • 10.1007/s11523-012-0251-8

PubMed ID

  • 23292310

Additional Document Info

volume

  • 8

issue

  • 3