Lung adenocarcinoma in the era of targeted therapies: histological classification, sample prioritization, and predictive biomarkers. Academic Article uri icon

Overview

abstract

  • The arrival of targeted therapies has presented both a conceptual and a practical challenge in the treatment of patients with advanced non-small cell lung carcinomas (NSCLCs). The relationship of these treatments with specific histologies and predictive biomarkers has made the handling of biopsies the key factor for success. In this study, we highlight the balance between precise histological diagnosis and the practice of conducting multiple predictive assays simultaneously. This can only be achieved where there is a commitment to multidisciplinary working by the tumor board to ensure that a sensible protocol is applied. This proposal for prioritizing samples includes both recent technological advances and the some of the latest discoveries in the molecular classification of NSCLCs.

publication date

  • January 29, 2013

Research

keywords

  • Adenocarcinoma
  • Biomarkers, Tumor
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Identity

PubMed Central ID

  • PMC3695315

Scopus Document Identifier

  • 84879799050

Digital Object Identifier (DOI)

  • 10.1158/1535-7163.MCT-10-0994

PubMed ID

  • 23359174

Additional Document Info

volume

  • 15

issue

  • 7