Evaluation of response to induction chemotherapy in esophageal cancer: is barium esophagography or PET-CT useful? Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To determine whether sequential barium esophagograms can predict histopathological response to treatment in esophageal cancer. MATERIALS AND METHODS: Two radiologists retrospectively reviewed esophagograms pre- and post- chemotherapy in 32 patients for tumor length decrease of at least 15% and luminal width increase of at least 15%. Positron emission tomography-computed tomography (PET-CT) was reviewed for tumor maximum standardized uptake value (SUVmax) decrease of at least 35%. The reference standard was 90% or more tumor necrosis at histopathologic examination of the excised specimen. RESULTS: Pathologic response ranged from 10% to 100% necrosis. For prediction of tumor response, the sensitivity, specificity, positive and negative predictive values for length ranged from 43.8 to 56.3% and for width from 41.2% to 66.7% and for SUVmax from 47.1% to 53.3%. CONCLUSION: Performance characteristics for barium esophagograms in our group of patients were similar to PET-CT in predicting tumor response. Both tests were inadequate in predicting tumor response.

publication date

  • September 13, 2012

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Barium Sulfate
  • Esophageal Neoplasms
  • Induction Chemotherapy
  • Multimodal Imaging
  • Positron-Emission Tomography
  • Tomography, X-Ray Computed

Identity

Scopus Document Identifier

  • 84876740729

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2012.08.003

PubMed ID

  • 23601767

Additional Document Info

volume

  • 37

issue

  • 3