cAMP and mitochondria. Review uri icon

Overview

abstract

  • Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

publication date

  • May 1, 2013

Research

keywords

  • Cyclic AMP
  • Mitochondria
  • Second Messenger Systems

Identity

PubMed Central ID

  • PMC3870303

Scopus Document Identifier

  • 84878531701

Digital Object Identifier (DOI)

  • 10.1152/physiol.00004.2013

PubMed ID

  • 23636265

Additional Document Info

volume

  • 28

issue

  • 3