mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. uri icon

Overview

abstract

  • Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.

publication date

  • May 7, 2013

Identity

Scopus Document Identifier

  • 84877285156

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2013.04.018

PubMed ID

  • 23663734

Additional Document Info

volume

  • 17

issue

  • 5