High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart. Academic Article uri icon

Overview

abstract

  • A technique on high frame rate(28fps), high frequency co-registered ultrasound and photoacoustic imaging for visualizing zebrafish heart blood flow was demonstrated. This approach was achieved with a 40MHz light weight(0.38g) ring-type transducer, serving as the ultrasound transmitter and receiver, to allow an optic fiber, coupled with a 532nm laser, to be inserted into the hole. From the wire target study, axial resolutions of 38µm and 42µm were obtained for ultrasound and photoacoustic imaging, respectively. Carbon nanotubes were utilized as contrast agents to increase the flow signal level by 20dB in phantom studies, and zebrafish heart blood flow was successfully observed.

publication date

  • June 17, 2013

Research

keywords

  • Coronary Circulation
  • Echocardiography
  • Elasticity Imaging Techniques
  • Myocardial Perfusion Imaging
  • Photoacoustic Techniques
  • Rheology
  • Zebrafish

Identity

PubMed Central ID

  • PMC3726247

Scopus Document Identifier

  • 84879361496

Digital Object Identifier (DOI)

  • 10.1364/OE.21.014636

PubMed ID

  • 23787651

Additional Document Info

volume

  • 21

issue

  • 12