Toxoplasma gondii serology in HIV-infected patients: the development of central nervous system toxoplasmosis in AIDS. Academic Article uri icon

Overview

abstract

  • Central nervous system (CNS) toxoplasmosis is an important infectious complication of AIDS which requires prolonged treatment. Most cases occur in patients with serologic evidence of prior exposure and therefore appear to result from reactivation of a previously acquired infection. Antibody to Toxoplasma gondii was found in 130 out of 411 patients with AIDS (32%). Of these, CNS toxoplasmosis developed in 31 (24%). By survival analysis, the estimated probability of ever developing CNS infection in antibody-positive individuals was 28%, occurring in 26% of patients within 2 years of the onset of AIDS. All patients with HIV infection should be tested for antibody to T. gondii and monitored for any neurologic change. Methods of prophylaxis for CNS toxoplasmosis in these high-risk patients need to be developed.

publication date

  • June 1, 1990

Research

keywords

  • Acquired Immunodeficiency Syndrome
  • Antibodies, Protozoan
  • Central Nervous System Diseases
  • Toxoplasma
  • Toxoplasmosis

Identity

Scopus Document Identifier

  • 0025323614

PubMed ID

  • 2386617

Additional Document Info

volume

  • 4

issue

  • 6