Septins set the stage for Orai1 to bind STIM1 at ER-PM junctions. uri icon

Overview

abstract

  • The endoplasmic reticulum (ER) Ca(2+) sensor STIM1 recruits and activates the plasma membrane (PM) Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE). Reporting in Nature, Sharma et al. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

publication date

  • July 29, 2013

Research

keywords

  • Calcium
  • NFATC Transcription Factors
  • RNA Interference
  • RNA, Small Interfering
  • Septins

Identity

PubMed Central ID

  • PMC4026033

Scopus Document Identifier

  • 84880941877

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2013.07.012

PubMed ID

  • 23906061

Additional Document Info

volume

  • 26

issue

  • 2