Peritoneal carcinomatosis in patients with gastric cancer, and the role for surgical resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The aims of this study were to create a model of peritoneal carcinomatosis in patients with gastric cancer and to evaluates outcomes in patients with gastric cancer treated using surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: A single-institution cohort of patients with gastric cancer was analyzed according to the development of gastric cancer with peritoneal carcinomatosis (GCPC). Variables were evaluated using regression analysis. Kaplan-Meier analysis was used to evaluate outcomes after surgical resection, cytoreductive surgery, and HIPEC. RESULTS: Age ≤60 years and local tumor stage (T3/T4) were significantly associated with GCPC (odds ratio, 3.95 and 3.94, respectively). Thirty-six-month survival was 57% for patients without peritoneal disease and 39% for patients with GCPC. There was no significant trend of improved survival after surgical management or HIPEC. CONCLUSIONS: Age ≤60 years and T3/T4 tumor stage are risk factors for GCPC. Intermediate-term survival of patients with GCPC treated with surgical resection or cytoreductive surgery and HIPEC was not improved, though future research should address the possible benefits of aggressive approaches to the treatment of GCRC.

publication date

  • October 21, 2013

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Chemotherapy, Cancer, Regional Perfusion
  • Hyperthermia, Induced
  • Peritoneal Neoplasms
  • Stomach Neoplasms

Identity

Scopus Document Identifier

  • 84890433068

Digital Object Identifier (DOI)

  • 10.1016/j.amjsurg.2013.04.010

PubMed ID

  • 24157224

Additional Document Info

volume

  • 207

issue

  • 1