Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The number of adults with diabetes mellitus is increasing worldwide, particularly in Asia and Africa. In sub-Saharan Africa, renal complications of diabetes may go unrecognized due to limited diagnostic resources. The prevalence of chronic kidney disease (CKD) among adult diabetics in sub-Saharan Africa has not been well described. METHODS: This study was conducted at the diabetes mellitus clinic of Bugando Medical Centre in Mwanza, Tanzania. A total 369 consecutive adult diabetic patients were enrolled and interviewed. Each patient provided a urine sample for microalbuminuria and proteinuria and a blood sample for serum creatinine level. Estimated glomerular filtration rate (eGFR) was calculated using the Cockroft-Gault equation. CKD was staged according to the Kidney Disease Improving Global Outcomes system. RESULTS: A total of 309 (83.7%) study participants had CKD; 295 (80.0%) had significant albuminuria and 91 (24.7%) had eGFR < 60 ml/min. None of these patients were aware of their renal disease, and only 5 (1.3%) had a diagnosis of diabetic nephropathy recorded in their file. Older age was significantly associated with CKD in this population [OR 1.03, p = 0.03, 95%CI (1.00-1.05)]. CONCLUSIONS: Chronic kidney disease is highly prevalent among adult diabetic outpatients attending our clinic in Tanzania, but is usually undiagnosed. Nearly ΒΌ of patients had an eGFR low enough to require dose adjustment of diabetic medications. More diagnostic resources are needed for CKD screening among adults in Tanzania in order to slow progression and prevent complications.

publication date

  • August 31, 2013

Research

keywords

  • Ambulatory Care
  • Diabetes Mellitus
  • Diabetic Nephropathies
  • Renal Insufficiency, Chronic

Identity

PubMed Central ID

  • PMC3765892

Scopus Document Identifier

  • 84883168543

Digital Object Identifier (DOI)

  • 10.1186/1471-2369-14-183

PubMed ID

  • 24228774

Additional Document Info

volume

  • 14