Sphingosine 1-phosphate signalling. Review uri icon

Overview

abstract

  • Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.

publication date

  • January 1, 2014

Research

keywords

  • Lysophospholipids
  • Receptors, Lysosphingolipid
  • Sphingosine

Identity

PubMed Central ID

  • PMC3865745

Scopus Document Identifier

  • 84890509587

Digital Object Identifier (DOI)

  • 10.1242/dev.094805

PubMed ID

  • 24346695

Additional Document Info

volume

  • 141

issue

  • 1