Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study. Academic Article uri icon



  • RATIONALE: Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN. METHODS: Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured. RESULTS: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model. CONCLUSIONS: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.

publication date

  • February 19, 2014



  • Apolipoprotein A-I
  • Lung Injury
  • Lysophospholipids
  • Occupational Exposure
  • Particulate Matter


PubMed Central ID

  • PMC4306444

Scopus Document Identifier

  • 84894598501

Digital Object Identifier (DOI)

  • 10.3109/1354750X.2014.891047

PubMed ID

  • 24548082

Additional Document Info


  • 19


  • 2