Allostery and compartmentalization: old but not forgotten. Review uri icon

Overview

abstract

  • Homeostasis is an essential capability of all cells mediated by complex and diverse regulatory networks. Despite this complexity, many of the fundamental regulatory mechanisms used by cells have been evolutionarily conserved. It is thus somewhat surprising that the apparent physiologic significance of these mechanisms has been experimentally neglected. Here, we review 2 widely recognized regulatory mechanisms, allostery and compartmentalization, which exemplify this dissociation in our current understanding of the microbial pathogen, Mycobacterium tuberculosis.

publication date

  • March 5, 2014

Research

keywords

  • Allosteric Regulation
  • Cell Compartmentation
  • Mycobacterium tuberculosis
  • Stress, Physiological

Identity

PubMed Central ID

  • PMC5228163

Scopus Document Identifier

  • 84896753299

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2014.01.007

PubMed ID

  • 24607642

Additional Document Info

volume

  • 18