Regulation of mitochondrial morphology by lipids. Review uri icon

Overview

abstract

  • Although great progress has been made in identifying key protein factors that regulate mitochondrial morphology through mediating fission and fusion, signaling lipids are increasingly being recognized as important in the process as well. We review here roles that have been proposed for the signaling and bulk lipids cardiolipin, phosphatidic acid, lysophosphatidic acid, diacylglycerol, and phosphatidylethanolamine and the enzymes that generate or catabolize them in the regulation of mitochondrial morphology in yeast and mammals. Mutations in some of these enzymes are causal in a number of disease settings, highlighting the significance of controlling the lipid environment in this setting.

publication date

  • April 26, 2014

Research

keywords

  • Lipids
  • Mitochondria
  • Mitochondrial Dynamics

Identity

PubMed Central ID

  • PMC4146713

Scopus Document Identifier

  • 84906790613

Digital Object Identifier (DOI)

  • 10.1002/biof.1169

PubMed ID

  • 24771456

Additional Document Info

volume

  • 40

issue

  • 4