Is tumor (R)ejection by the immune system the "5th R" of radiobiology? Academic Article uri icon

Overview

abstract

  • Traditional factors of DNA damage and tumor cell kill, described by the "4 R's" of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a "5th R," (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.

publication date

  • March 7, 2014

Identity

PubMed Central ID

  • PMC4008452

PubMed ID

  • 24800177

Additional Document Info

volume

  • 3

issue

  • 1