Endogenous antibodies for tumor detection. Academic Article uri icon

Overview

abstract

  • The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find that in transgenic and xenograft mouse models of cancer, endogenous gamma immunoglobulin (IgG) is present at higher concentration in malignantly transformed organs compared to non-transformed organs in the same mouse or organs of cognate wild-type mice. The enrichment of endogenous antibodies within the malignant tissue provides a potential means of identifying and tracking malignant cells in vivo as they mutate and diversify. Exploiting these antibodies for diagnostic and therapeutic purposes is possible through the use of agents that bind endogenous antibodies.

publication date

  • May 30, 2014

Research

keywords

  • Biomarkers, Tumor
  • Immunoassay
  • Immunoglobulin G
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC4038850

Scopus Document Identifier

  • 84901797783

Digital Object Identifier (DOI)

  • 10.1038/srep05088

PubMed ID

  • 24875800

Additional Document Info

volume

  • 4