Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. METHODS: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. RESULTS: The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p = .001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. CONCLUSION: Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.

publication date

  • July 24, 2014

Research

keywords

  • Carcinoma, Adenoid Cystic
  • Head and Neck Neoplasms
  • Lymph Nodes
  • Neck
  • Neck Dissection

Identity

PubMed Central ID

  • PMC4988229

Scopus Document Identifier

  • 84931570833

Digital Object Identifier (DOI)

  • 10.1002/hed.23711

PubMed ID

  • 25060927

Additional Document Info

volume

  • 37

issue

  • 7