Small fiber abnormalities in skin biopsies of patients with benign fasciculations. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To determine whether patients with benign fasciculations have evidence for axonal loss in skin biopsies. METHODS: Epidermal sensory and sweat gland nerve fiber densities were quantified in skin biopsies of 11 patients with benign fasciculations and no other known cause for neuropathy. RESULTS: Nine of the 11 patients (82%) had significantly reduced epidermal or sweat gland nerve fiber densities at the calf or thigh, in comparison with control values. CONCLUSIONS: The presence of reduced epidermal and sweat gland nerve fiber density indicates the presence of axonal loss in patients with benign fasciculations.

publication date

  • September 1, 2014

Research

keywords

  • Fasciculation
  • Nerve Fibers
  • Skin

Identity

Scopus Document Identifier

  • 84906818357

Digital Object Identifier (DOI)

  • 10.1097/CND.0000000000000047

PubMed ID

  • 25137510

Additional Document Info

volume

  • 16

issue

  • 1