Genetic effects on refraction and correlation with hemodynamic variables: a twin study. Academic Article uri icon

Overview

abstract

  • Spherical equivalent (SE) has not been linked to increased cardiovascular morbidity. Methods: 132 Hungarian twins(age 43.3±16.9 years) underwent refraction measurements (Huvitz MRK-3100 Premium AutoRefractokeratometer)and oscillometry (TensioMed Arteriograph). Results: Heritability analysis indicated major role for genetic components in the presence of right and left SE (82.7%, 95%CI, 62.9 to 93.7%, and 89.3%, 95%CI, 72.8 to 96.6%),while unshared environmental effects accounted for 17% (95%CI, 6.3% to 37%), and 11% (95%CI, 3.4% to 26.7%)of variations adjusted for age and sex. Bilateral SE showed weak age-dependent correlations with augmentation index (AIx), aortic pulse wave velocity (r ranging between 0.218 and 0.389, all p < 0.01), aortic systolic blood pressure and pulse pressure (r between 0.188 and 0.289, p < 0.05). Conclusions: These findings support heritability of spherical equivalent, which does not coexist with altered hemodynamics (e.g. accelerated arterial aging).Accordingly, SE and the investigated hemodynamic parameters seem neither phenotypically nor genetically associated.

publication date

  • September 1, 2014

Research

keywords

  • Hemodynamics
  • Refraction, Ocular
  • Twins, Dizygotic
  • Twins, Monozygotic

Identity

Scopus Document Identifier

  • 84907009762

Digital Object Identifier (DOI)

  • 10.1556/APhysiol.101.2014.3.6

PubMed ID

  • 25183505

Additional Document Info

volume

  • 101

issue

  • 3