Genomics-based early-phase clinical trials in oncology: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies. Academic Article uri icon

Overview

abstract

  • The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force discussed incorporation of genomic profiling into early (Phase I and II) clinical trials in oncology. The task force reviewed the challenges of standardising genomics data in a manner conducive to conducting clinical trials. Current barriers to successful and efficient implementation were identified and discussed, as well as the methods of genomic analysis, the proper setting for study and strategies to facilitate timely completion of genomics-based studies. The importance of properly capturing and cataloguing outcomes was also discussed. Several recommendations regarding the use of genomics in these trials are provided.

publication date

  • September 15, 2014

Research

keywords

  • Genomics
  • Medical Oncology
  • Neoplasms

Identity

Scopus Document Identifier

  • 84925457305

Digital Object Identifier (DOI)

  • 10.1016/j.ejca.2014.07.027

PubMed ID

  • 25227487

Additional Document Info

volume

  • 50

issue

  • 16