Repair and tissue engineering techniques for articular cartilage. Review uri icon

Overview

abstract

  • Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that biologic agents can delay the advancement of deterioration, such drugs are incapable of promoting tissue restoration. The limited ability of articular cartilage to regenerate renders joint arthroplasty an unavoidable surgical intervention. This Review describes current, widely used clinical repair techniques for resurfacing articular cartilage defects; short-term and long-term clinical outcomes of these techniques are discussed. Also reviewed is a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular cartilage. Acellular products typically consist of collagen or hyaluronic-acid-based materials, whereas cellular techniques use either primary cells or stem cells, with or without scaffolds. Central to these efforts is the prominent role that tissue engineering has in translating biological technology into clinical products; therefore, concomitant regulatory processes are also discussed.

publication date

  • September 23, 2014

Research

keywords

  • Cartilage, Articular
  • Chondrocytes
  • Osteoarthritis
  • Tissue Engineering

Identity

PubMed Central ID

  • PMC4629810

Scopus Document Identifier

  • 84926337395

Digital Object Identifier (DOI)

  • 10.1038/nrrheum.2014.157

PubMed ID

  • 25247412

Additional Document Info

volume

  • 11

issue

  • 1