Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. Academic Article uri icon

Overview

abstract

  • Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

publication date

  • September 25, 2014

Research

keywords

  • Breast Neoplasms
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Hispanic or Latino
  • White People
  • Whites

Identity

PubMed Central ID

  • PMC4428554

Scopus Document Identifier

  • 84911117895

Digital Object Identifier (DOI)

  • 10.3109/07357907.2014.958232

PubMed ID

  • 25254601

Additional Document Info

volume

  • 32

issue

  • 9