Management of postmenopausal osteoporosis. Review uri icon

Overview

abstract

  • A hallmark of menopause, which follows the decline in the ovarian production of estrogen, is the aggressive and persistent loss of bone mineral and structural elements leading to loss of bone strength and increased fracture risk. This review focuses on newer methods of diagnosing osteoporosis and assessing fracture risk, as well as on novel management strategies for prevention and treatment. Fracture-risk prediction has been significantly enhanced by the development of methods such as the trabecular bone score, which helps assess bone microarchitecture and adds value to standard bone densitometry, and the Fracture Risk Assessment Tool (FRAX) algorithm techniques. The treatment of osteoporosis, which has the goals of fracture prevention and risk reduction, is moving beyond traditional monotherapies with antiresorptives and anabolic agents into new combination regimens.

publication date

  • October 29, 2014

Research

keywords

  • Bone Density Conservation Agents
  • Osteoporosis, Postmenopausal
  • Osteoporotic Fractures

Identity

Scopus Document Identifier

  • 84921395889

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-070313-022841

PubMed ID

  • 25386933

Additional Document Info

volume

  • 66