Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease. Review uri icon

Overview

abstract

  • Resting heart rate is central to cardiac output and is influenced by changes occurring in numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence suggests that it is also an important marker of outcome in cardiovascular disease, including heart failure. Beta-blockers improve outcomes in heart failure; however, they have effects outside reducing heart rate. Ivabradine has demonstrated efficacy in reducing rehospitalizations and mortality in heart failure and in improving exercise tolerance and reducing angina attacks in patients with coronary artery disease, whereas selective heart rate reduction may also prove to be beneficial in therapeutic areas outside those in which ivabradine has already demonstrated clinical efficacy. This review provides an update on the associations between heart rate and cardiovascular outcomes in various conditions, the experimental effects of heart rate reduction with ivabradine, and the potential new indications in cardiovascular disease.

publication date

  • October 15, 2014

Research

keywords

  • Benzazepines
  • Cardiovascular Diseases
  • Heart Rate
  • Rest

Identity

Scopus Document Identifier

  • 84924077422

Digital Object Identifier (DOI)

  • 10.1016/j.amjmed.2014.09.016

PubMed ID

  • 25447617

Additional Document Info

volume

  • 128

issue

  • 3