CD8+ T-cells count in acute myocardial infarction in HIV disease in a predominantly male cohort. Academic Article uri icon

Overview

abstract

  • Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (>1065 cells/mm3) had increased AMI risk (adjusted HR=1.82, P<0.001, 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8+ T-cell tertiles on AMI risk differed by CD4+ T-cell level: compared to uninfected people, HIV-infected people with CD4+ T-cell counts≥200 cells/mm3 had increased AMI risk with high CD8+ T-cell count, while those with CD4+ T-cell counts<200 cells/mm3 had increased AMI risk with low CD8+ T-cell count. CD8+ T-cell counts may add additional AMI risk stratification information beyond that provided by CD4+ T-cell counts alone.

publication date

  • January 19, 2015

Research

keywords

  • CD8-Positive T-Lymphocytes
  • HIV Infections
  • Myocardial Infarction

Identity

PubMed Central ID

  • PMC4320893

Scopus Document Identifier

  • 84922350837

Digital Object Identifier (DOI)

  • 10.1155/2015/246870

PubMed ID

  • 25688354

Additional Document Info

volume

  • 2015