Soft tissue sarcoma of the head & neck: nomogram validation and analysis of staging systems. Academic Article uri icon

Overview

abstract

  • BACKGROUND AND OBJECTIVES: Soft tissue sarcomas of the head and neck (STSHN) comprise a rare group of malignancies. Our objective is to determine the utility of soft tissue sarcoma staging systems within the head and neck, and to validate an individualized soft tissue sarcoma nomogram within head and neck primary sites. METHODS: Previously-untreated patients with STSHN diagnosed and treated between 1982 and 2012 were eligible (n = 319, median follow-up 46 months). Clinical variables were extracted from a prospectively-maintained database. The performance of AJCC/UICC and MSK staging systems and a soft tissue sarcoma-specific nomogram were assessed. RESULTS: Four-year overall survival (OS), disease specific survival (DSS), and recurrence-free survival (RFS) were 72%, 76%, and 71%, respectively. AJCC/UICC and MSK staging systems accurately stratified outcomes (OS, DSS, and RFS; P < 0.001 for all comparisons). The nomogram stratified outcomes by quartile (P < 0.001), and predicted risk of death at 4, 8 and 12 years (P < 0.001). Concordance indices for overall survival for the AJCC/UICC system, MSK system, and the nomogram were 0.71, 0.70, and 0.78, respectively. CONCLUSIONS: Oncologic outcomes among groups of patients with STSHN can be accurately predicted using both the AJCC/UICC and MSK staging systems. A soft tissue sarcoma-specific nomogram provides reliable, individualized prognostic information for patients with STSHN.

publication date

  • February 24, 2015

Research

keywords

  • Head and Neck Neoplasms
  • Neoplasm Staging
  • Nomograms
  • Sarcoma

Identity

PubMed Central ID

  • PMC5827948

Scopus Document Identifier

  • 84928211659

Digital Object Identifier (DOI)

  • 10.1002/jso.23868

PubMed ID

  • 25711850

Additional Document Info

volume

  • 111

issue

  • 6