The journey from discoveries in fundamental immunology to cancer immunotherapy. Review uri icon

Overview

abstract

  • Recent advances in cancer immunotherapy have directly built on 50 years of fundamental and technological advances that made checkpoint blockade and T cell engineering possible. In this review, we intend to show that research, not specifically designed to bring relief or cure to any particular disease, can, when creatively exploited, lead to spectacular results in the management of cancer. The discovery of thymus immune function, T cells, and immune surveillance bore the seeds for today's targeted immune interventions and chimeric antigen receptors.

publication date

  • April 6, 2015

Research

keywords

  • Allergy and Immunology
  • Immunotherapy
  • Neoplasms
  • Research

Identity

Scopus Document Identifier

  • 84928056873

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2015.03.007

PubMed ID

  • 25858803

Additional Document Info

volume

  • 27

issue

  • 4