Evaluation of Initial Telomere Length and Changes after Transplantation in Adult Double-Unit Cord Blood Transplant Recipients. Academic Article uri icon

Overview

abstract

  • Cord blood (CB) leukocytes have inherent telomere length (TL) variation, and CB hematopoietic stem cells (HSC) can maintain high telomerase levels preventing telomere attrition in vitro. We evaluated TL changes in 13 adult double-unit CB transplant (CBT) recipients. In the 26 units, we observed a marked variation in CB TL at thaw (median, 9.99 kilobases [kb]; range, 6.85 to 13.5). All 13 patients engrafted. Of 11 engrafting with 1 unit, there was no correlation between unit dominance and TL (mean dominant unit TL, 8.84 kb ± 1.76; mean nonengrafting unit TL, 10.3 kb ± 1.81; P = .77). Serial measurements of TL up to 1 year after CBT demonstrated an overall mean 3.04 kb ± .16 TL decrease with only 1 patient exhibiting telomere maintenance. In summary, initial TL does not predict CB unit dominance. Moreover, our analysis suggests neonatal hematopoiesis makes a transition to an HSC characterized by changes in average TL and potentially low telomerase asymmetric cell division in adult CBT recipients. Further investigation of alterations in telomere length and its clinical implications after transplantation of this observation are indicated.

publication date

  • April 10, 2015

Research

keywords

  • Cord Blood Stem Cell Transplantation
  • Hematologic Neoplasms
  • Myeloablative Agonists
  • Telomere
  • Telomere Homeostasis
  • Transplantation Conditioning

Identity

PubMed Central ID

  • PMC4466009

Scopus Document Identifier

  • 84930581779

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2015.04.006

PubMed ID

  • 25865647

Additional Document Info

volume

  • 21

issue

  • 7