Carotid sparing intensity-modulated radiation therapy achieves comparable locoregional control to conventional radiotherapy in T1-2N0 laryngeal carcinoma. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Although intensity-modulated radiotherapy (IMRT) is a standard of care for many head and neck cancers, its use for carotid-sparing (CS) therapy in early-stage laryngeal carcinoma is controversial. METHODS: 330 consecutive patients with early-stage laryngeal carcinoma were treated from 1/1989 to 5/2011, including 282 conventional radiotherapy (CRT) and 48 CS-IMRT patients. The median follow-up was 43 (CS-IMRT) and 66 (CRT) months. RESULTS: There was no difference in local failure rates comparing patients undergoing CS-IMRT with CRT, with 3-year local control rates of 88% vs. 89%, respectively (p=0.938). Using a 1cm circumferential margin, the average dose to the left and right carotid arteries was 48.3 and 47.9 Gy, respectively. 88% of locoregional recurrences involved the ipsilateral true vocal cord, including all local recurrences in the IMRT group. CONCLUSIONS: These results warrant further prospective evaluation of CS-IMRT for early-stage glottic larynx cancer.

publication date

  • May 7, 2015

Research

keywords

  • Carcinoma, Squamous Cell
  • Glottis
  • Laryngeal Neoplasms
  • Neoplasm Recurrence, Local
  • Radiotherapy, Intensity-Modulated

Identity

PubMed Central ID

  • PMC5508531

Scopus Document Identifier

  • 84931566149

Digital Object Identifier (DOI)

  • 10.1016/j.oraloncology.2015.02.003

PubMed ID

  • 25958831

Additional Document Info

volume

  • 51

issue

  • 7