Arrhythmias in the setting of hematopoietic cell transplants. Academic Article uri icon

Overview

abstract

  • Prior studies report that 9-27% of persons receiving a hematopoietic cell transplant develop arrhythmias, but the effect on outcomes is largely unknown. We reviewed data from 1177 consecutive patients ⩾40 years old receiving a hematopoietic cell transplant at one center during 1999-2009. Transplant indication was predominately leukemia, lymphoma and multiple myeloma. Overall, 104 patients were found to have clinically significant arrhythmia: 43 before and 61 after transplant. Post-transplant arrhythmias were most frequently atrial fibrillation (N=30), atrial flutter (N=7) and supraventricular tachycardia (N=11). Subjects with an arrhythmia post transplant were more likely to have longer median hospital stays (32 days vs 23, P=<0.001), a greater probability of an intensive care unit admission (52% vs 7%; P<0.001), greater probability of in-hospital deaths (28% vs 3%, P<0.001), and greater probability of death within 1 year of transplant (41% vs 15%; P<0.001) compared with patients without arrhythmia at any time. In a multivariate model including age at transplant, diagnosis, history of pretransplant arrhythmia, and transplant-related variables, post-transplant arrhythmia was associated with a greater risk for death within a year of transplant (odds ratio 3.5, 95% confidence interval: 2.1, 5.9; P<0.001). Our data suggest that arrhythmias after transplants are associated with significant morbidity and mortality. A prospective study of arrhythmia in the transplant setting is warranted.

publication date

  • June 1, 2015

Research

keywords

  • Arrhythmias, Cardiac
  • Hematopoietic Stem Cell Transplantation
  • Hospital Mortality
  • Length of Stay
  • Models, Biological

Identity

PubMed Central ID

  • PMC4558298

Scopus Document Identifier

  • 84940899928

Digital Object Identifier (DOI)

  • 10.1038/bmt.2015.127

PubMed ID

  • 26030046

Additional Document Info

volume

  • 50

issue

  • 9