CD1a-positive dendritic cell density predicts disease-free survival in papillary thyroid carcinoma. Academic Article uri icon

Overview

abstract

  • OBJECTIVES: Dendritic cells are common in inflammatory processes and in papillary thyroid carcinoma (PTC). Previous studies of the predictive value of S100-positive dendritic cell density for PTC outcome yielded inconsistent results. This study investigated the association of dendritic cell density and PTC recurrence based on CD1a expression. METHODS: Representative slides from 56 consecutive specimens of PTC were immunostained with anti-CD1a antibodies, and dendritic cell density was analyzed by disease-free survival. RESULTS: Dendritic cells were abundant in the tumoral tissue and sparse in the normal peritumoral tissue. Peritumoral dendritic cell density >1.1 cells/HPF was inversely associated with the risk of recurrence. Similar results were obtained with tumoral dendritic cell density (>12 cells/HPF), although the statistical significance was marginal. CONCLUSIONS: High CD1a-positive dendritic cell density is associated with improved disease-free survival in PTC. The specificity of anti-CD1a immunostain for activated dendritic cells may explain the better outcome prediction in this study than in studies using S100 protein.

publication date

  • May 27, 2015

Research

keywords

  • Antigens, CD1
  • Biomarkers, Tumor
  • Carcinoma
  • Dendritic Cells
  • Thyroid Neoplasms

Identity

Scopus Document Identifier

  • 84938748985

Digital Object Identifier (DOI)

  • 10.1016/j.prp.2015.05.009

PubMed ID

  • 26073685

Additional Document Info

volume

  • 211

issue

  • 9