Treatment of Leptomeningeal Carcinomatosis in a Patient With Metastatic Cholangiocarcinoma. uri icon

Overview

abstract

  • A 49-year-old woman with cholangiocarcinoma metastatic to the lungs presented with new-onset unrelenting headaches. A lumbar puncture revealed malignant cells consistent with leptomeningeal metastasis from her cholangiocarcinoma. Magnetic resonance imaging (MRI) of the brain revealed leptomeningeal enhancement. An intrathecal (IT) catheter was placed and IT chemotherapy was initiated with methotrexate. Her case is notable for the rarity of cholangiocarcinoma spread to the leptomeninges, the use of IT chemotherapy with cytologic and potentially symptomatic response, and a possible survival benefit in comparison to previously reported cases of leptomeningeal carcinomatosis secondary to cholangiocarcinoma.

publication date

  • October 10, 2014

Identity

PubMed Central ID

  • PMC4435345

Digital Object Identifier (DOI)

  • 10.14309/crj.2014.78

PubMed ID

  • 26157901

Additional Document Info

volume

  • 2

issue

  • 1