Dectin-1 Exerts Dual Control in the Gut. uri icon

Overview

abstract

  • Dectin-1, a β-glucan receptor, contributes to host anti-fungal defense. In this issue of Cell Host & Microbe, Tang et al. (2015) show that suppressing Dectin-1 signaling protects mice from experimental colitis by decreasing anti-microbial peptide production, which allows overgrowth of Lactobacilli and triggers T regulatory cell expansion in the gut.

publication date

  • August 12, 2015

Research

keywords

  • Colitis
  • Colon
  • Lactobacillus
  • Lectins, C-Type
  • Signal Transduction
  • T-Lymphocytes, Regulatory

Identity

PubMed Central ID

  • PMC4605567

Scopus Document Identifier

  • 84959325504

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2015.07.010

PubMed ID

  • 26269949

Additional Document Info

volume

  • 18

issue

  • 2