Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. CONCLUSIONS: This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers.

publication date

  • September 26, 2015

Research

keywords

  • Antibodies, Neutralizing
  • HIV Antibodies
  • HIV-1
  • env Gene Products, Human Immunodeficiency Virus

Identity

PubMed Central ID

  • PMC4583754

Scopus Document Identifier

  • 84942254962

Digital Object Identifier (DOI)

  • 10.1186/s12977-015-0210-4

PubMed ID

  • 26410741

Additional Document Info

volume

  • 12