Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Academic Article uri icon

Overview

abstract

  • The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.

publication date

  • October 12, 2015

Research

keywords

  • Gene Expression Regulation, Neoplastic
  • Genetic Variation
  • Neoplasms
  • RNA, Long Noncoding

Identity

PubMed Central ID

  • PMC4777353

Scopus Document Identifier

  • 84944077358

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2015.09.006

PubMed ID

  • 26461095

Additional Document Info

volume

  • 28

issue

  • 4