siRNA Nanoparticles for Ultra-Long Gene Silencing In Vivo. Academic Article uri icon

Overview

abstract

  • Small interfering RNA (siRNA)-mediated gene silencing has shown prominent therapeutic effects in treating various diseases. However, adequate delivery and persistent gene silencing remain challenging. A nanoparticle-based delivery system which assembled by layering siRNAs between protease degradable polypeptides to show ultra-long gene silencing effect in vivo is developed. Gold nanoparticle is used as a scaffold for its unique properties including uniform size, biocompatibility, ready synthesis, and easy functionalization. A simple layer-by-layer fabrication approach, based on the electrostatic interaction between positively and negatively charged polymers, is applied to package the therapeutic siRNAs.

publication date

  • January 1, 2016

Research

keywords

  • Gene Expression
  • Gene Silencing
  • Nanoparticles
  • RNA Interference
  • RNA, Small Interfering

Identity

Scopus Document Identifier

  • 84946571465

Digital Object Identifier (DOI)

  • 10.1007/978-1-4939-3148-4_9

PubMed ID

  • 26530919

Additional Document Info

volume

  • 1372