Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais. Academic Article uri icon

Overview

abstract

  • HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+)non-classical monocytes were associated with worse neuropsychological test performance (r=0.43, p=0.024). CCR2(+)non-classical monocyte count inversely correlated with CSF neopterin (r=-0.43, p=0.035) and plasma TNF-α levels (r=-0.40, p=0.041). These data benchmark CCR2(+)non-classical monocytes as an independent index of cognitive impairment.

authors

  • Ndhlovu, Lishomwa (Lish)
  • D'Antoni, Michelle L
  • Ananworanich, Jintanat
  • Byron, Mary Margaret
  • Chalermchai, Thep
  • Sithinamsuwan, Pasiri
  • Tipsuk, Somporn
  • Ho, Erika
  • Slike, Bonnie M
  • Schuetz, Alexandra
  • Zhang, Guangxiang
  • Agsalda-Garcia, Melissa
  • Shiramizu, Bruce
  • Shikuma, Cecilia M
  • Valcour, Victor

publication date

  • September 4, 2015

Research

keywords

  • AIDS Dementia Complex
  • Cognition Disorders
  • Monocytes

Identity

PubMed Central ID

  • PMC4633708

Scopus Document Identifier

  • 84945543480

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2015.08.020

PubMed ID

  • 26531691

Additional Document Info

volume

  • 288