Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST). Review uri icon

Overview

abstract

  • Neuropathic pain often develops following nerve injury as a result of maladaptive changes that occur in the injured nerve and along the nociceptive pathways of the peripheral and central nervous systems. Multiple cellular and molecular mechanisms likely account for these changes; however, the exact nature of these mechanisms remain largely unknown. A growing number of studies suggest that alteration in gene expression is an important step in the progression from acute to chronic pain states and epigenetic regulation has been proposed to drive this change in gene expression. In this review, we discuss recent evidence that the DNA-binding protein neuron-restrictive silencing factor/repressor element-1 silencing transcription factor (NRSF/REST) is an important component in the development and maintenance of neuropathic pain through its role as a transcriptional regulator for a select subset of genes that it normally represses during development.

publication date

  • December 8, 2015

Research

keywords

  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Neuralgia
  • Repressor Proteins

Identity

PubMed Central ID

  • PMC4899316

Scopus Document Identifier

  • 84975717690

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2015.12.003

PubMed ID

  • 26679228

Additional Document Info

volume

  • 625