TOPBP1 takes RADical command in recombinational DNA repair. uri icon

Overview

abstract

  • TOPBP1 is a key player in DNA replication and DNA damage signaling. In this issue, Moudry et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507042) uncover a crucial role for TOPBP1 in DNA repair by revealing its requirement for RAD51 loading during repair of double strand breaks by homologous recombination.

publication date

  • January 25, 2016

Research

keywords

  • Carrier Proteins
  • Chromatin
  • Chromatin Assembly and Disassembly
  • DNA-Binding Proteins
  • Homologous Recombination
  • Nuclear Proteins
  • Ovarian Neoplasms
  • Phthalazines
  • Piperazines
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Rad51 Recombinase

Identity

PubMed Central ID

  • PMC4748579

Scopus Document Identifier

  • 84959565722

Digital Object Identifier (DOI)

  • 10.1083/jcb.201601028

PubMed ID

  • 26811424

Additional Document Info

volume

  • 212

issue

  • 3