False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load. Academic Article uri icon

Overview

abstract

  • We report investigation of 22 TB cases with positive Xpert MTB/RIF result for resistance to Rifampin and "Very Low" MTB detection level. Twelve cases were false positive without rpoB mutations, 2 were false-positives with a silent mutation in rpoB codon T508, and only 10 were true positives.

publication date

  • January 15, 2016

Research

keywords

  • Bacterial Load
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis
  • Real-Time Polymerase Chain Reaction
  • Rifampin
  • Tuberculosis, Multidrug-Resistant

Identity

PubMed Central ID

  • PMC4841693

Scopus Document Identifier

  • 84963782594

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2016.01.009

PubMed ID

  • 26915638

Additional Document Info

volume

  • 85

issue

  • 1