Oxcarbazepine-induced liver injury after sensitization by valproic acid: a case report. uri icon

Overview

abstract

  • OBJECTIVE: The aim of the present case report is to describe a potential interaction between valproic acid and oxcarbazepine that resulted in hepatic injury. METHODS: We report the case of a 46-year-old man with schizoaffective disorder who was cross-titrated from valproic acid to oxcarbazepine because of liver injury. RESULTS: Initiation of oxcarbazepine four days after stopping valproic acid produced a significant elevation in liver enzymes that normalized with oxcarbazepine discontinuation and did not reappear with its reintroduction five days later. CONCLUSIONS: Our findings suggest that a longer washout period or another agent should be considered when transitioning from valproic acid to oxcarbazepine.

publication date

  • April 4, 2016

Identity

Scopus Document Identifier

  • 84963632097

Digital Object Identifier (DOI)

  • 10.1111/bdi.12381

PubMed ID

  • 27041538

Additional Document Info

volume

  • 18

issue

  • 3