Mechanisms of Perineural Invasion. Review uri icon

Overview

abstract

  • Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as an important adverse pathological feature of many malignancies, including pancreatic, prostate, and head and neck cancers and is associated with a poor prognosis. Despite widespread acknowledgment of the clinical significance of PNI, the mechanisms underlying its pathogenesis remain largely unknown. Recent theories of PNI pathogenesis have placed a significant emphasis on the active role of the nerve microenvironment, with PNI resulting from well-orchestrated reciprocal interactions between cancer and host. Elucidating the mechanisms involved in PNI may translate into targeted therapies for this ominous process.

publication date

  • March 10, 2016

Identity

PubMed Central ID

  • PMC4846411

Scopus Document Identifier

  • 84966430842

Digital Object Identifier (DOI)

  • 10.1055/s-0036-1571835

PubMed ID

  • 27123385

Additional Document Info

volume

  • 77

issue

  • 2