Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Academic Article uri icon

Overview

abstract

  • Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.

authors

publication date

  • April 20, 2016

Research

keywords

  • Breast Neoplasms
  • Colorectal Neoplasms
  • Lung Neoplasms
  • Ovarian Neoplasms
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC5010493

Scopus Document Identifier

  • 84986888945

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-15-2980

PubMed ID

  • 27197191

Additional Document Info

volume

  • 76

issue

  • 17