Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo. Academic Article uri icon

Overview

abstract

  • When added to a collagen-filled nerve guide, purified acidic fibroblast growth factor (aFGF) increased the number of myelinated axons that regenerated across a 5-mm nerve gap distance. In addition, a greater number of primary sensory and motor neurons extended axons through the nerve guide in animals treated with aFGF. Thus the effect of aFGF on peripheral nerve regeneration is not simply an increase in axonal branching within the nerve guide tube. This is the first highly purified growth factor since nerve growth factor that has been shown to promote nerve regeneration in vivo. This experimental model provides a convenient and quantitative means to assess the effects of putative neuronotropic factors on peripheral nerve regeneration in vivo.

publication date

  • June 1, 1989

Research

keywords

  • Fibroblast Growth Factors
  • Nerve Regeneration
  • Peripheral Nerves

Identity

Scopus Document Identifier

  • 0024402506

PubMed ID

  • 2727148

Additional Document Info

volume

  • 83

issue

  • 6