Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis? MATERIALS AND METHODS: Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest. RESULTS: Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01). CONCLUSION: Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis.

publication date

  • May 24, 2016

Research

keywords

  • Contrast Media
  • Gadolinium DTPA
  • Liver
  • Liver Cirrhosis

Identity

Scopus Document Identifier

  • 84973354171

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2016.05.004

PubMed ID

  • 27288740

Additional Document Info

volume

  • 40

issue

  • 5