Pathophysiology of Birth Asphyxia. Review uri icon

Overview

abstract

  • The pathophysiology of asphyxia generally results from interruption of placental blood flow with resultant fetal hypoxia, hypercarbia, and acidosis. Circulatory and noncirculatory adaptive mechanisms exist that allow the fetus to cope with asphyxia and preserve vital organ function. With severe and/or prolonged insults, these compensatory mechanisms fail, resulting in hypoxic ischemic injury, leading to cell death via necrosis and apoptosis. Permanent brain injury is the most severe long-term consequence of perinatal asphyxia. The severity and location of injury is influenced by the mechanisms of injury, including degree and duration, as well as the developmental maturity of the brain.

publication date

  • June 17, 2016

Research

keywords

  • Acidosis
  • Asphyxia Neonatorum
  • Brain
  • Fetal Hypoxia
  • Hypercapnia
  • Hypoxia, Brain

Identity

Scopus Document Identifier

  • 84981736300

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2016.04.002

PubMed ID

  • 27524444

Additional Document Info

volume

  • 43

issue

  • 3