An emerging role for IQGAP1 in tight junction control. Review uri icon

Overview

abstract

  • IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.

publication date

  • November 23, 2016

Research

keywords

  • Tight Junctions
  • ras GTPase-Activating Proteins

Identity

PubMed Central ID

  • PMC5997139

Scopus Document Identifier

  • 84996841806

Digital Object Identifier (DOI)

  • 10.1080/21541248.2016.1244440

PubMed ID

  • 27880081

Additional Document Info

volume

  • 9

issue

  • 5