Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation. Academic Article uri icon

Overview

abstract

  • We aimed to identify whether the use of autologous hematopoietic cell transplantation (HCT) impacts outcomes for multiple myeloma patients with gains of chromosome 1q (+1q). We retrospectively identified 95 patients, 21% having +1q. For patients with +1q, the overall response rate to induction was 85%, with 40% having ≥ VGPR and 20% achieving a CR, similar to non +1q patients (p = .64). The median PFS from diagnosis with +1q was 2.1 years (95% CI: 1.2-not reached (NR)) vs 4.3 years (95% CI: 3.3 yrs-NR) without +1q (p = .003). Median OS from diagnosis was 4.4 years (95% CI: 2.9-NR) vs not reached, respectively (p = .005). On molecular analysis using the Foundation One Heme assay, the most common mutations seen in +1q patients included TP53 (38%) and KRAS (25%). Overall, gain of 1q portends worse PFS and OS which was not negated by auto HCT. Such patients will likely require additional therapy to improve their survival.

publication date

  • January 12, 2017

Research

keywords

  • Chromosome Duplication
  • Chromosomes, Human, Pair 1
  • Multiple Myeloma

Identity

PubMed Central ID

  • PMC5554510

Scopus Document Identifier

  • 85009247798

Digital Object Identifier (DOI)

  • 10.1080/10428194.2016.1260126

PubMed ID

  • 28078910

Additional Document Info

volume

  • 58

issue

  • 8